Grants for UB Ophthalmology Research Total $1M Over 9 Years – UB School of Medicine and Biomedical Sciences

“I look forward to the day when these research results will be translated into clinical therapies and cures that will improve or restore vision for those with visual disabilities and prevent vision loss.”

 

In 2014, University at Buffalo ophthalmology researchers
supported by these funds made several discoveries, resulting in 17
publications in peer-reviewed journals, including PloS One,
Developmental Neurobiology, the Proceedings of the National Academy
of Sciences and the American Journal of Pathology.

 

, led
research suggesting that modulation of the UPR and ER stress
machinery offers potential new therapeutic targets for preventing
or minimizing retinal degenerative diseases.

 

Other UPR-related studies led by Zhang were published in the
Journal of Ophthalmic and Vision Research, the Journal of Diabetes
Research and Antioxidants and Redox Signaling.

 

, assistant professor of ophthalmology, led
research examining differences in the effects of carbonic anhydrase
(CA) inhibitors on endothelial ion transport in bovine versus human
corneas ex vivo.

 

The researchers found that CA inhibitors do not produce corneal
swelling in humans, suggesting alternative corneal endothelial ion
transport mechanisms may exist.

 

, and colleagues examined the mechanisms by which
retinal progenitor cells (RPCs) are directed by gene transcription
factors to differentiate into retinal ganglion cells (RGCs) during
development.

 

Curated from Grants for UB Ophthalmology Research Total $1M Over 9 Years – UB School of Medicine and Biomedical Sciences